Paint. Reveal. Score.

Fold or Flop

Paint the protein based on how confident you think the AI prediction is. Then reveal the answer and score your guess.

Choose your challenge

Difficulty

Daily Challenge

What is this? How does it work?

How to play

1. Paint

Brush each region with your confidence guess — high, medium, or low.

2. Reveal

See the real AlphaFold confidence map overlaid on your guess.

3. Score

Get a score based on how close your intuition was.

Curated challenges

Pick a protein

Start small or work your way up. Every card launches the game.

Challenge 1EasyHemoglobin alphaUniProt P69905Play challenge Challenge 2EasyInsulinUniProt P01308Play challenge Challenge 3Mediump53UniProt P04637Play challenge Challenge 4HardEGFRUniProt P00533Play challenge

Why this exists

Molecular weirdness, made playable.

I like computational biology because it turns invisible molecular weirdness into something you can actually play with. Fold or Flop started from one small question: if AI can predict a protein’s shape, can we learn to spot where it’s secretly unsure?